It all depends on the developers of the applications. If they released a USB dongle, then yes, you can use it while connected to the USB port, but I believe it will cost extra for this job and then there is a another cheap solution that actually works. Use Amazon or your local IT shop/website and look for a COM/SERIAL/Parallel to USB adapter. It will allow you to connect your Dongle to the USB through an adapter. All you need to do is to install the drivers and it should work normally.