Yes, you will have to set up two separate "virtual cables" in order to run FLdigi and MARS-M110A MDT on Flex 5000a because these are two distinct products. However, in order to connect the device to your computer, you will need only a single cable. I recommend you contact the Flex 5000a's manufacturer for further details. You can get in touch with them using the contact details from the official web page.