Error 646 is directly related to the AppData folder that is improperly defined in the registry database of your computer. Microsoft was aware of this problem and issued a fix for it.
Go to Start > Run and type regedit then navigate to the following key:
HKEY_LOCAL_MACHINE\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folders\
The AppData path should look like: %USERPROFILE%\AppData\Roaming
Double click to change it and then perform another update attempt. If the error persists repeat the same procedure for the following keys in the registry editor:
After there fixes, everything should be back to normal.