No, MSN Emoticons Plus is an old application that has been discontinued and it is no longer supported by its developer. It is not compatible with the latest versions of Outlook. As an alternative, I suggest you use Topalt Emoticons for Outlook. It works with Outlook 2013, Outlook 2010, Outlook 2007 and Outlook 2003 and can run on both 32 and 64bit Windows platforms.
