It doesn't start because your computer doesn't meet the minimum system requirements or the installation files are corrupted. The minimum requirements to play Total Overdose are:
- OS: Windows 2000/XP;
- CPU: Pentium 4 or Athlon XP with 1.5 GHz;
- RAM: 256 MB;
- Video Card: 32 MB DirectX 9 compatible video card (GeForce3 TI+ / Radeon 8500+);
- Free Disk Space: 360 MB.
If these requirements are fulfilled, update your video card drivers and reinstall the game.