If you tried to give full control over the EXE file, and it didn't work, you can try to delete the User profile that can't run the program. This might be corrupted. Then make another account, with the same rights, set the appropriate privileges for this one from right clicking the EXE file > Properties > Security, and then run the program. If the same behavior is encountered, log in with the Administrator, open the program and go under File > Agent Profile > HiPath ProCenter Administrator Guide to learn more about the application's needs or check the Help menu.