Will PC Backup work with Windows 10?
No, the application is not compatible with Windows 10, because it has been discontinued. When you try to access the official homepage of the product, you are greeted with a message that says the product isn't available anymore.
Official website: http://www.droboworks.com/Drobo-PC-Backup.asp
You might need to use another application since this one isn't available for backup.
Another application you can use is Acronis True Image 2016: http://www.acronis.com/en-us/personal/computer-backup/