No, from what it seems, you can't use HOMA calculator to assess insulin sensitivity and resistance of Wistar rats in experimental model of type II DM. The application uses the HOMA2 model to estimate beta cell function (%B) and insulin sensitivity (%S) for an individual from simultaneously measured fasting plasma glucose and fasting plasma RIA insulin values. I recommend that you contact the official developers for further details. You can get in touch with them using +44 (0)1865 857233 phone number or homa.calculator@dtu.ox.ac.uk email address.
