This seems to be a fairly common issue. To fix it, go to the path where you installed the game. By default, this should be C:/Program Files/Pirates of the Caribbean. If you are using Windows 7 or Windows Vista, make sure that you install the game in any other directory out of Program Files. In the above mentioned location, start the config.exe and make sure that safe mode is unchecked. After you did this, start the game. You should be able to play it. For additional information, check the game's forum.