Apart from UnLocker, I would also recommend if you have TuneUp installed there, then that can also unlock a running application, however, just a backfill for any kind of context menu applicators, please make sure things are saved within your files. Also, if anything is copied onto your copy handler, make sure that there is only copied things & not cut pasted things ongoing or running, or at times these appliacations, break the operation & your files get corrupted.
:)