The system requirements mention Windows 10 as a supported operating system which means you can install and it in this operating system. When installing choose Run As Administrator to avoid any other issues. I suspect the loading issues are caused by the lack of Administrator permissions that allow Print Artist to access the files stored on the system partition.
Since I can't install the software due to the commercial license that is in effect, I suggest getting in touch with the developers to explain the problem with their software.
