Unfortunately, the latest update for USB Disk Manager came all the way back in 2011, so the tool isn't exactly designed to work with Windows 10. However, I installed it on my Windows 10 PC and I was able to run it without any issues. Additionally, even if, for some reason, the application's window isn't visible on your desktop, you still have access to all the settings, by right-clicking the icon from the system tray, as seen in the picture below.
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