Yes, the SAP CRM is compatible with Windows 10. According to a discussion found on the official website for communities that are working with SAP, it's listed that Windows 10 is found among the supported operating systems. However, it might sound easy, but the whole process isn't. You will have to make sure that various components are also updated in order to make the jump to Windows 10.
Use the following link as guidance and always read the installation manual for your software before attempting an upgrade: https://scn.sap.com/thread/3779681