Yes, Lotus SmartSuite is compatible with Windows 10. I have seen users that managed to upgrade Windows 8.1 to Windows 10 and they still have Lotus functionality. However, if you plan to install it from scratch, then I recommend running the installation package as administrator. Don't use the automated install wizard that appears when you insert the CD. Explore the CD and launch the installer manually using Run as Administrator.
Note: Version that works is Lotus SmartSuite 9.8.2.