No, version 3.5 is not compatible with Windows 10. Version 4 is not compatible as well. The only version that has been released compatible to Windows 10 is MediaShout 5. This is, in fact, the latest one released by the developers.
- Windows 7, Windows 8/8.1, or Windows 10.
- Primary display needs to be 1280x768 or higher.
- PowerPoint 2010 recommended for PPT integration.
- Dedicated, dual-head NVIDIA or ATI/AMD video card w/ 512MB DDR3 RAM (Suggested Cards)
- Intel Core2Duo Processor running at 2.5GHz equivalent or better.
- 4GB RAM.
More about the software on the following page: http://www.mediashout.com/products/mediashout5