The most common problems related to printing are caused by lacking the driver installation, corrupted files, missing paper, printer unplugged, etc.
Firstly, I would check if the printer is connected and installed. Make sure the cable is attached to PC and the printer is correctly installed in Device Manager. Go to Start > Run > devmgmt.msc and check its installation. If it isn't installed, right-click it and select Update Driver then follow the installation guidelines.
In the Print menu inside Label Creator, select the default printer and then initiate the printing procedure.