There is no information on the Internet about the compatibility for Power Presenter RE II. I recommend you to use the Compatibility Mode. Right click on its executable file and select Proprieties. Select from there the Compatibility tab and choose the a Windows version from "Run this program in compatibility mode for:". You can go through the same steps for Microsoft Office 2013, but I am a Microsoft Office 2013 user, and I can tell you that this application works right with Windows 8.