Even if the device is connected to the PC, it will not work, if you receive the main application error. Try to uninstall any drivers and software, then perform a fresh installation. If everything goes well, the application will stop showing the error message. The software might be bugged and the only way to fix this error is to update it. You can either check if it can be updated via a built-in updater or download another one from its official website. It's not a public download and you will need to contact the developer in order to download it.
