These applications have been marked as malicious. It's recommended to uninstall them as soon as possible.
Try using Revo Uninstaller. Even if it can't uninstall the application normally, it will force it to uninstall by wiping out all traces of its presence from the system.
After that, try running AdwCleaner to make sure that there are no leftover rogue registry keys or toolbars in your system.
If AdwCleaner didn't remove them, try using Combofix.