Serious Sam 3 is a game that requires a high-end computer. It may also experience problems running it on a powerful PC but if the settings are not configured properly. However, try updating the drivers for your graphics card and DirectX. The sound driver should be updated as well. Since most of the sound cards are embedded in the motherboard, you can download the updated driver from the manufacturer's website. Simply paste the model of your motherboard in Google search and you'll be able to download them. Once you have finished these operations, try running the game again. If it will run, go to Settings > Graphics and lower the settings until the game it's playable.