Yes. You can use Ductputer to calculate the pressure drop in duct work. However, you should know that this product was found un-safe while scanning it with the most used protection applications. For further information in this matter, check the following page from Software Informer.
Regarding the question asked, I suggest that you take a look at SF Pressure Drop. Even if it's shareware, this application is developed specially to calculate the pressure drop.
