When trying to run the upgraded version, that cryptic popup message generally means the drive/location of iTunes can't be found. Follow these quick/short instructions to check drive management, first (start by performing a "warm" boot, or "Restart"):
- After your system is ready and you've logged in with "Administrator's" Permission Hold the key down and press the key. This opens up your quick Run box - you can run most any program from there. Type the following into the input box that's presented to you, then hit :
mmc diskmgmt.msc
This will directly up the "Disk Management" snap in, where many different options can be made to your various drives.
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Look over status of your drive management system, to see that your drives are as they should be. You can also double-click (Left Mouse Button) on which the drive where iTunes is installed; this is just to verify the path to and all files for iTunes are as they should be. Double-click iTunes.exe - should be found in the path (based on the default installation on Drive C:), to verify that it runs without the error popup.
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Close out of everything you've opened that may still be open when you are done.
The next easy option is simply to Open your Control Panel, then double-click on the icon entitled "Programs and Features." When fully loaded and open you'll see a long listing of all installed Programs and files. Find the iTunes entry and double-click to uninstall; once completed, you should perform a Reboot and unplug the system's power cord completely, leaving it OFF for at least 15-30 secs (this helps to ensure that all memory is 100% blank, without any residual bits/bytes of code/data left behind that could possibly cause sporadic problems later on (which is what occurs with a Restart or "Warm" boot).
Reboot once more, then when your logged back in with "administrator's" Permission, turn OFF your AV, malware protection and firewall (don't be scared - as AV programs are becoming more entwined into the opsys, it's prudent to
turn it off, just before installing and turning on immediately after). Lastly, you could try installing in "Safe" mode. I hope this is of some help!