In order to uninstall the application you can follow the steps provided by Trend Micro, the developer of the product. You will need to download the security agent Uninstall Tool and to log on to Windows as administrator.
Also you can try using Revo Uninstaller. Even if it can't uninstall the application normally, it will force it to uninstall by wiping out all traces of its presence from the system.
After that, try running AdwCleaner to make sure that there are no leftover rogue registry keys or toolbars in your system.