No, ISYS:desktop is not compatible with Windows 10. I've analyzed the official website and found out it supports only these versions of Windows: Windows 95/98/ME and Windows NT/2000/XP.
If this application is critical to your business, you can install Windows XP using VirtualBox and then transfer the ISYS:desktop in that environment. There are some requirements that you can see below.
- Windows XP installation disc
- A PC with medium-high processing power
- 8GB RAM or more to assign to virtual machine
- A motherboard with support for virtualization.