Jyotishya Deepika is not working on Windows 10 because the developers even mentioned this on their official website:
What is NOT SUPPORTED:
-Windows 8 operating system
-Net Books running on ATOM processors are NOT supported.
-Monitor resolution of 800 x 600 is NOT supported.
-MAC computers and non-windows operating systems are NOT supported.
As you can see, it doesn't even have support for Windows 8. It's meaningless to attempt to run it if it doesn't even have support for NET Framework 4.5