The PCCloneEX was used to back up 2.5" and 3.5" external HDDs. However, it would be possible to create a clone of the HDD, but the problem with PCCloneEX is related its availability. You can still download it, but it hasn't been updated in a long time and I don't know if it will work properly.
I advise using an application that is constantly updated and meet the latest standards. For additional examples, access the following link.