No, the application won't work on OS X because it's not compatible with this operating system. I've checked various sources and everyone says that American Greetings isn't compatible with Mac.
There is a way to run it through virtualization, meaning that you have to install Windows through one of the supported apps and then run American Greetings CreataCard in this way. It might be a tedious process which requires medium-high knowledge, but it should get the job done.
Start with Parallels Desktop and a tutorial:
