Yes it definitely can work in Windows 10. At first it did not for me, but back in February 2016 a CPP tech sent me 3 files needed to make it work. Once I added them all was good. Let me know at email@example.com if you need those files. Sadly, I have tried and tried to contact CPP and it seems they have abandoned the Card Collector program without notice. The website URL now goes to a Beckett site, that does not respond to any inquiries. I keep asking, but get no answers. I have 350k plus cards in my databases, and want to find a replacement software that can import my data, but so far no luck. So I just keep using TCC to catalog my collection even though I cannot get updated values.