Apparently the application is not restricted to work only on Asus motherboards because I have downloaded the setup package and installed it. Regarding this matter, I can affirmatively answer your question: you can install it on other motherboards because the application working in my computer is on a MSI motherboard so you can see that it can be installed. The actual working part is something in question because it may need Asus hardware which is found only on their motherboards. So you see that the application installs correctly but the functioning part is in doubt because there are other components on MSI motherboards than Asus. Give it a try because the application is just like any other and cannot harm your computer.