No, the application is not compatible with the Windows 10 operating system. You can install it only on Windows 2000, XP, Vista, and 7. In Windows 10, you can apply a compatibility tweak to make it work, but no one will guarantee if it will work or not.
System Requirements page: http://www.matchware.com/en/products/mediator/productinfo/syst_require.htm
Note: If the software is maintained regularly, it should get the compatibility upgrade in the near feature, but it's best to hear this from the developers. Use the following email to contact them: