Yes, SpeechMike III and Nuance RadWhere are fully compatible. Also, Nuance RadWhere can work with Olympus DR-2100, DR-2300, DR-1200, DR-2200, Dictaphone PowerMic II, Andrea ANC300 and Grundig Digta SonicMic II devices. If you have issues, I suggest you contact Nuance using the information from the official web page.