From what it seems, the software is not correctly installed or some of its files are corrupted. Also, it is possible to not be compatible with your system. In order to fix the issue, I suggest you remove Microsoft Expression Design using its uninstaller or Add or Remove Programs feature (Control Panel > Uninstall a program) and download and install its latest version. Microsoft Expression Design 4 is fully compatible with Windows 8, Windows 7, Windows Vista and Windows XP on both 32 and 64-bit architecture. Also, make sure you have installed .NET Framework 4.0 and Microsoft Silverlight.