The latest version of MediaPortal2 is 2.1.1 and it's listed as being compatible with the Windows 10 operating systems. These are the system requirements:
CPU: Intel P4 with 2.0 GHz / AMD XP-2000+ or above
Memory: 1024 MB
HDD: 600 MB for MediaPortal
HDD: 50 GB for TV recordings and time shifting. Recordings can take up to 8GB per hour
Video card: DirectX 9 compatible video card with at least 128 MB of video memory
TV card: MediaPortal TV-Server supports all analog TV cards with hardware MPEG-2 encoder and all digital TV cards which use BDA-drivers.
As you can see, if your card supports MPEG-2 encoder and BDA-Drivers, then it can be used. As always, I strongly recommend checking the available setup guides for the software through this link.