That means PTC ProDESKTOP encountered a serious error and needs to close. The error could have many causes, and you should start testing the ones you can. For example, the first thing to do is to fix the program's integrity. Simply go to Uninstall a program in Control Panel and repair the installation of PTC ProDESKTOP then restart the application.
Secondly, make sure that you have all the necessary requirements for the program to function correctly (eg. Visual Runtime C++, Net Framework, additional independent modules).
Lastly, use the antivirus solution on your PC and scan for possible infections. It's known that trojans and viruses corrupt application's files.