No, Betabrite XL doesn't work on Windows 10. According to system requirements found on multiple websites, you can run the application on the following versions of Windows: Windows 2000, XP, Vista, and Windows 7.
In Windows 10, you have to run it as Administrator. If the package is on your PC, right-click it and choose Run as Administrator. You will be prompted to log in with a username that has Administrator rights if yours isn't configured for such process.