It's impossible to say if the software is compatible with the Windows 10 operating system because the official website redirects to something else other then what it supposed to be there in the first place. I believe the software has been replaced with something else or discontinued at all.
You should get in touch with the developers to ask them about this inquiry: +1-800-722-1227
Or use the info on the contact page: http://endnote.com/contact