Yes, Memorex exPressit Label Design Studio works on Windows 10. I couldn't find an official website for the application and it's EULA expired several years ago, which means that the program has most likely been discontinued. However, I used the download link from Software Informer, installed the application on a Windows 10 Home computer and it ran just fine.
In case you're interested, the same developer, Microvision Development, created a newer tool called Disk Labeler, which you might want to check out.
