By default, the Web Player is compatible with the following browsers: Internet Explorer, Firefox, Chrome, Safari, and Opera. As you can see, it supports most known Internet browsers released to date. Yes, the software works with Mac browsers like Safari, and it can be installed on Mac OS X as well.
It supports:
Mac: Mac OS X 10.6 or newer
Windows: Windows XP, Vista, 7, and 8.
Download page: https://unity3d.com/webplayer
