Developers insist you avoid having multiple security solutions installed to overcome conflicts. This is the only read someone will indicate you disable another security product if you want to install a different one. Yes, the program will work with System Mechanic Pro installed as long as you disable the anti-exploit/anti-malware protection in System Mechanic Pro (if there is one). For example, if you have 2 security solutions installed and both detect a malware file, then both applications will attempt to remove the file. Since the file is accessed by 2 independent applications, the procedure will cause file and memory conflicts, therefore destabilizing computer's functionality.